Vietnam veteran John Rambo has survived many harrowing ordeals in his lifetime and has since withdrawn into a simple and secluded existence in Thailand, where he spends his time capturing snakes for local entertainers, and chauffeuring locals in his old PT boat.

Even though he is looking to avoid trouble, trouble has a way of finding him: a group of Christian human rights missionaries, led by Michael Burnett and Sarah Miller, approach Rambo with the desire to rent his boat to travel up the river to Burma. For over fifty years, Burma has been a war zone. The Karen people of the region, who consist of peasants and farmers, have endured brutally oppressive rule from the murderous Burmese military and have been struggling for survival every single day. After some inner contemplation, Rambo accepts the offer and takes Michael, Sarah, and the rest of the missionaries up the river. When the missionaries finally arrive at the Karen village, they find themselves part of a raid by the sadistic Major Pa Tee Tint and a slew of Burmese army men.

A portion of the villagers and missionaries are tortured and viciously murdered, while Tint and his men hold the remainder captive. Concerned by their disappearance, the minister in charge of the mission gathers a group of mercenaries and pleas Rambo transport them with his boat, since he knows their last exact location. But Rambo can't stay behind: he joins the team where he belongs, to liberate the survivors from the clutches of Major Tint in what may be one of his deadliest missions ever.

Directed by Sylvester Stallone

Writing credits (WGA) - Art Monterastelli and Sylvester Stallone

Cast (in credits order)

Sylvester Stallone ... John Rambo
Julie Benz ... Sarah
Matthew Marsden ... School Boy
Graham McTavish ... Lewis
Reynaldo Gallegos ... Diaz (as Rey Gallegos)
Jake La Botz ... Reese
Tim Kang ... En-Joo
Maung Maung Khin ... Major Pa Tee Tint
Paul Schulze ... Michael Burnett
Cameron Pearson ... Jeff - Missionary #4
Thomas Peterson ... Dentist - Missionary #2
Tony Skarberg ... Videographer - Missionary #3
James With ... Preacher - Missionary #5 (as James Wearing Smith)
Kasikorn Niyompattana ... Snake Hunter #2
Shaliew Manrungbun ... Snake Hunter #1
Supakorn Kitsuwon ... Myint
Aung Aay Noi ... Lt. Aye
Ken Howard ... Rev. Arthur Marsh
Aung Theng ... Pirate Leader
Pornpop Kampusiri ... Snake Village Owner
Wasawat Panyarat ... Snake Village MC
Kammul Kawtep ... Snake Village Young Charmer
Sornram Patchimtasanakarn ... Tha
Noa Jei ... Karen Interpreter #1
Kjan Saen ... Karen Interpreter #2
Aun Lung Su ... Burmese Hut Guard #1
Pan Dokngam ... Burmese Hut Guard #2
Han Pik ... Burmese Hut Guard #3
Tip Tiya ... Burmese Gate Guard #2
Nee Lungjai ... Burmese Gate Guard #1
Yupin Mu Pae ... Karen Begging Mother
Moan Adisak ... Burmese Morning Guard #1
Somsak Wongsa ... Burmese Dancer Trooper #1
Surachai Muangdee ... Burmese Dancer Trooper #2
Mana Sen-Mi ... Burmese Patrol Boat Captain
Toole Khan Kham ... Burmese Sergeant
Saiwan Lungta ... Burmese Trooper – Lt. Aye's Hut
Warcharentr Sedtho ... Burmese Young Boy
Rapimpa Dibu ... Karen Young Naked Girl
May Kung ... Pirate Bar Hooker #1

Original Music by Brian Tyler
Cinematography by Glen MacPherson (director of photography)
Film Editing by Sean Albertson
Casting by Sheila Jaffe
Production Design by Franco-Giacomo Carbone
Art Direction by Suchartanun 'Kai' Kuladee
Set Decoration by Witoon Suanyai
Costume Design by Lizz Wolf

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